Inhibiting initiation — targeting BMI1 is effective
نویسندگان
چکیده
منابع مشابه
Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism.
Epigenetic dysregulation is involved in the initiation and progression of many epithelial cancers. BMI1, a component of the polycomb protein family, plays a key role in these processes by controlling the histone ubiquitination and long-term repression of multiple genomic loci. BMI1 has previously been implicated in pancreatic homeostasis and the function of pancreatic cancer stem cells. However...
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متن کاملRetraction: Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence
We the authors are retracting this Article as it has come to our attention that there has been inappropriate duplication of images between different figures of the published paper, and between figures in the paper and those in work previously published by the corresponding author (Hidalgo, I. et al. 2012). The figure panels affected are Figure 1d, Figure 3c, Figure 4e, Figures 6a, g, and Supple...
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ژورنال
عنوان ژورنال: Nature Reviews Urology
سال: 2016
ISSN: 1759-4812,1759-4820
DOI: 10.1038/nrurol.2016.131